Dr. Mario Fernández Ruiz, specialist doctor of the Infectious Diseases Unit led by Dr. José María Aguado and attached to the Area of »Infectious Diseases and AIDS» of the Research Institute Hospital 12 de Octubre (i + 12), has received the 2020 ICHS Young Investigator Award awarded by the International Immunocompromised Host Society, a society…
PCZ salvage therapy, especially oral tablets, can be an effective alternative option for patients with IFI who cannot tolerate or do not respond to other antifungal therapies. This is the result of a collaborative multicentre study carried out in six tertiary hospitals in Spain to evaluate the use of PCZ in different forms of…
The increase of multidrug-resistant carbapenemase-producing Enterobacteriaceae is a major public health threat associated with significant morbidity and mortality, and mainly due to Klebsiella pneumoniae and Escherichia coli. However, there is little information about carbapenemase-producing (CP) Klebsiella oxytoca, an important nosocomial pathogen. We characterized CP K. oxytoca isolates collected from different Spanish hospitals between January 2016…
Voriconazole is a triazole antifungal agent recommended as primary treatment for invasive aspergillosis, as well as some other mold infections. However, it presents some pharmacokinetic singularities that lead to a great variability intra and interindividually, nonlinear pharmacokinetics, and a narrow therapeutic range. Most experts have recommended tracing the levels of voriconazole in patients when receiving…
A recently published multicenter study led by Dr. Mario Fernández-Ruiz and Prof. José María Aguado, from the University Hospital “12 de Octubre” (Madrid), has confirmed the usefulness of a immune-based monitoring strategy to predict the risk of potentially severe opportunistic infections due to the reactivation of cytomegalovirus (CMV) in patients undergoing kidney transplantation. The study…
MODERN is an international collaborative project investigating the reservoirs and transmission of Enterobacteriaceae producing extended-spectrum β-lactamases (ESBL-E), funded by national institutions participating in the Joint Programme Initiative – Antimicrobial Resistance (JPI AMR) of the European Union with 1 million Euros. The project is coordinated by Hospital Universitario Virgen Macarena/University of Seville/Institute of Biomedicine of Seville,…
Last December the journal “Medical Mycology” published a multicenter study of adult patients with candidemia in 13 hospitals in Spain, lead by investigators of Bellvitge University Hospital. Candidemia is a common infection and is associated with high morbidity and mortality. Outcomes of patients with candidemia may be directly influenced by the general management, including diagnostic…
Journal of Antimicrobial Chemotherapy 2018 (In press) This study was coordinated at University Hospital Virgen Macarena in collaboration with the Centro Nacional de Biotecnología. This work shows that suppression of the SOS response (through recA deleted) blocks the evolution towards clinical quinolone resistance across a range of E. coli phenotypes from highly susceptible to highly…
The sharp increase in cases of MDR Acinetobacter baumannii infections in recent years prompted by WHO to list this pathogen as a critical pathogen. The development of new approaches that adjuvant the scarcity of clinically relevant antibiotics for treatment of infections by MDR A. baumannii is an urgent need. Researchers from the University Hospital Virgen…
In a recent publication (Annual Reviews of Microbiology), scientists belonging to REIPI (Centro Nacional de Biotecnología, Hospital Virgen del Rocío and Hospital Ramón y Cajal), in collaboration with the Université París Descartes-CNRS, have called the attention on the dangerous side effects of antibiotics because of their capacity to accelerate the rise of antibiotic resistant bacteria.…
El Hospital Universitario Germans Trias i Pujol organiza la jornada internacional sobre resistencia a los antibióticos denominada “The Challenge of MDR and XDR infections”. Esta jornada tendrá lugar el día 14 de Septiembre en Casa de la Convalescencia, Barcelona. Toda la información de registro está en <http://www.fls-science.com/mdr-infections> www.fls-science.com/mdr-infections
La resistencia a los antifúngicos está aumentando por la aparición de nuevas especies resistentes y por el desarrollo de resistencia en especies sensibles, posiblemente por el uso y abuso de los mismos. Un trabajo previo realizado en España (FILPOP1) reveló niveles de resistencia a los azoles en hongos filamentosos entre el 10 y el 12,7%,…
Antifungal resistance is increasing by the emergence of intrinsically resistant species and by the development of secondary resistance in susceptible species. A previous study performed in Spain revealed levels of azole resistance in molds between 10 to 12.7% but secondary resistance in A. fumigatus was not detected. We used itraconazole supplemented media to select resistant…
-El hallazgo representa un cambio epidemiológico en la distribución de las betalactamasas de espectro extendido (BLEEs) en Europa. -El trabajo es resultado de la colaboración de los Servicios de Medicina Preventiva y Microbiología en el Hospital Universitario Ramón y Cajal (Madrid) en un estudio multicéntrico europeo (R-GNOSIS) financiado por la UE y ha sido premiado…
– This finding represents an epidemiological change in extended-expectrum-beta-lactamases (ESBLs) distribution in Europe – This study results from the collaboration of the Preventive Medicine and Microbiology Departments at Hospital Universitario Ramón y Cajal (Madrid) with a European multicentre project (R-GNOSIS) funded by the EU and it has been recently awarded as best communication in the…
The digital transformation of public procurement will bring huge changes to the sector, but it also offers increased competitiveness of our economies.
The digital transformation of public procurement will bring huge changes to the sector, but it also offers increased competitiveness of our economies.
