Dr. Mario Fernández Ruiz, receives the 2020 ICHS Young Investigator Award

Dr. Mario Fernández Ruiz, specialist doctor of the Infectious Diseases Unit led by Dr. José María Aguado and attached to the Area of ​​»Infectious Diseases and AIDS» of the Research Institute Hospital 12 de Octubre (i + 12), has received the 2020 ICHS Young Investigator Award awarded by the International Immunocompromised Host Society, a society…

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Posaconazole Salvage Therapy: The Posifi Study

  PCZ salvage therapy, especially oral tablets, can be an effective alternative option for patients with IFI who cannot tolerate or do not respond to other antifungal therapies. This is the result of a collaborative multicentre study carried out in six tertiary hospitals in Spain to evaluate the use of PCZ in different forms of…

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Characterization of carbapenemase-producing Klebsiella oxytoca in Spain, 2016-2017

The increase of multidrug-resistant carbapenemase-producing Enterobacteriaceae is a major public health threat associated with significant morbidity and mortality, and mainly due to Klebsiella pneumoniae and Escherichia coli. However, there is little information about carbapenemase-producing (CP) Klebsiella oxytoca, an important nosocomial pathogen. We characterized CP K. oxytoca isolates collected from different Spanish hospitals between January 2016…

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The Mycology Reference Laboratory-CNM, a group that belongs to REIPI, recently published the following method in the AAC journal: High-Resolution Melting assay for genotyping variants of the CYP2C19 enzyme and predicting Voriconazole effectiveness

Voriconazole is a triazole antifungal agent recommended as primary treatment for invasive aspergillosis, as well as some other mold infections. However, it presents some pharmacokinetic singularities that lead to a great variability intra and interindividually, nonlinear pharmacokinetics, and a narrow therapeutic range. Most experts have recommended tracing the levels of voriconazole in patients when receiving…

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