PCZ salvage therapy, especially oral tablets, can be an effective alternative option for patients with IFI who cannot tolerate or do not respond to other antifungal therapies. This is the result of a collaborative multicentre study carried out in six tertiary hospitals in Spain to evaluate the use of PCZ in different forms of…
The increase of multidrug-resistant carbapenemase-producing Enterobacteriaceae is a major public health threat associated with significant morbidity and mortality, and mainly due to Klebsiella pneumoniae and Escherichia coli. However, there is little information about carbapenemase-producing (CP) Klebsiella oxytoca, an important nosocomial pathogen. We characterized CP K. oxytoca isolates collected from different Spanish hospitals between January 2016…
Voriconazole is a triazole antifungal agent recommended as primary treatment for invasive aspergillosis, as well as some other mold infections. However, it presents some pharmacokinetic singularities that lead to a great variability intra and interindividually, nonlinear pharmacokinetics, and a narrow therapeutic range. Most experts have recommended tracing the levels of voriconazole in patients when receiving…
A recently published multicenter study led by Dr. Mario Fernández-Ruiz and Prof. José María Aguado, from the University Hospital “12 de Octubre” (Madrid), has confirmed the usefulness of a immune-based monitoring strategy to predict the risk of potentially severe opportunistic infections due to the reactivation of cytomegalovirus (CMV) in patients undergoing kidney transplantation. The study…