D) Progam "Emerging problems with high impact on Public Health"
1. To reduce the morbidity and mortality of the severe flu
Line 1. Clinical and prognostic evaluation and co-infections.
Action 1
To determine the utility of the prognosis scales in the decision of hopitalization and ICU admission.
Responsible: Hospital Universitario Son Espases
Action 2
To determine the epidemiological and clinical characteristics, treatment and evolution of the pneumonia caused by influenza A(H1N1) 2009 in the post-pandemic stage.
Responsible: Hospital Universitario Bellvitge
Action 3
To determine the impact of the viral and/or bacterial co-infection on the prognosis of pneumonia affected patients.
Responsible: Hospital Universitario Bellvitge
Line 2. Immune response and disease prevention.
Action 1
Analysis of the innate immune system factors implicated in the resopnse to the infection caused by influenza.
Responsible: Centro Investigaciones Biológicas
Action 2
To determine the pharmacokinetic and antiviral activity of oseltamivir in patient affected by pneumonia.
Responsible: Hospital Unversitario Bellvitge
Line 3. Treatment of the disease.
Action 1
To determine the pharmacokinetic and antiviral activity of oseltamivir in patient affected by pneumonia.
Responsible: Hospital Universitario Virgen del Rocío. Dra. Teresa Allende Aydillo.
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Action 2
To determine the relevance of the viral loading and the resistance to oseltamivir in patients prognosis.
Responsible: Hospital Universitario Bellvitge
2. To reduce the incidence and to better the prognosis of the flu in solid organ transplant receptor.
Line 1. Clinical evaluation, prognosis and co-infections
Action 1
Observational prospective clinical study of flu in solid organ transplant receptors.
Responsible: Estudio internacional y multicéntrico de la America Society of Transplantation (AST) coordinado por la Universidad de Alberta (Canadá).
Line 2. Prevention of the disease.
Action 1
Prospective randomized clinical trial comparing the efficacy and security of the dose of seasonal vaccine to two doses of vaccines as prevention of flu in solid organ transplant receptors.
Responsible: Hospital Universitario Virgen del Rocío. Dra. Elisa Cordero.
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Line 3. Knowledge Transfer.
Action 1
Clinical practice guide on the management of flu in solid organ transplant receptors.
Responsible: Hospital Universitario 12 de Octubre. Dr. Francisco López.
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